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Cell Immunol. 2013 Mar;282(1):17-20. doi: 10.1016/j.cellimm.2013.04.008. Epub 2013 Apr 26.

CD147 in regulatory T cells.

Author information

1
Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, P.O. Box 1125 Blindern, N-0318 Oslo, Norway.

Abstract

CD147 or EMMPRIN belongs to the immunoglobulin superfamily of membrane receptors and is expressed in epithelial cells, cancer cells and T cells of the immune system. In T cells CD147 functions as a receptor for soluble cyclophilins and is involved in chemotaxis. We recently reported its expression to high levels and association with suppressive function in regulatory T cells. Here, we discuss its potential application as a marker of activated regulatory T cells.

PMID:
23665204
DOI:
10.1016/j.cellimm.2013.04.008
[Indexed for MEDLINE]

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