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Neuron. 2013 May 8;78(3):405-8. doi: 10.1016/j.neuron.2013.04.034.

RAN translation: fragile X in the running.

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1
Program of Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada.

Abstract

In this issue of Neuron, Todd et al. (2013) reveal that noncanonical repeat associated non-AUG (RAN) translation occurs on nonexpanded (CGG)30-50 and premutation (CGG)59-160 repeats, associated with the FMR1 gene, suggesting that the polyglycine and polyalanine products might have natural and pathogenic roles.

PMID:
23664607
DOI:
10.1016/j.neuron.2013.04.034
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