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Trends Mol Med. 2013 Jul;19(7):406-9. doi: 10.1016/j.molmed.2013.04.003. Epub 2013 May 8.

Painful Na-channelopathies: an expanding universe.

Author information

1
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA. stephen.waxman@yale.edu

Abstract

The universe of painful Na-channelopathies--human disorders caused by mutations in voltage-gated sodium channels--has recently expanded in three dimensions. We now know that mutations of sodium channels cause not only rare genetic 'model disorders' such as inherited erythromelalgia and channelopathy-associated insensitivity to pain but also common painful neuropathies. We have learned that mutations of NaV1.8, as well as mutations of NaV1.7, can cause painful Na-channelopathies. Moreover, recent studies combining atomic level structural models and pharmacogenomics suggest that the goal of genomically guided pain therapy may not be unrealistic.

PMID:
23664154
DOI:
10.1016/j.molmed.2013.04.003
[Indexed for MEDLINE]

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