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J Enzyme Inhib Med Chem. 2014 Jun;29(3):408-19. doi: 10.3109/14756366.2013.793184. Epub 2013 May 10.

Design, synthesis and biological evaluation of novel inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors.

Author information

1
Global Discovery, Nycomed: a Takeda Company, Nycomed GmbH , Konstanz , Germany .

Abstract

This study is based on our attempts to further explore the structure-activity relationship (SAR) of VX-148 (3) in an attempt to identify inosine 5'-mono-phosphate dehydrogenase (IMPDH) inhibitors superior to mycophenolic acid. A five-point pharmacophore developed using structurally diverse, known IMPDH inhibitors guided further design of novel analogs of 3. Several conventional as well as novel medicinal chemistry strategies were tried. The combined structure- and ligand-based approaches culminated in a few analogs with either retained or slightly higher potency. The compounds which retained the potency were also checked for their ability to inhibit human peripheral blood mononuclear cells proliferation. This study illuminates the stringent structural requirements and strict SAR for IMPDH II inhibition.

KEYWORDS:

3D pharmacophore; IMPDH; VX-148; advanced chemical analog; immunosuppressant

PMID:
23663081
DOI:
10.3109/14756366.2013.793184
[Indexed for MEDLINE]

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