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Clin Genet. 2013 Nov;84(5):397-406. doi: 10.1111/cge.12190. Epub 2013 Jun 10.

Funding considerations for the disclosure of genetic incidental findings in biobank research.

Author information

1
Department of Human Genetics, Faculty of Medicine, Centre of Genomics and Policy, McGill University, Montreal, Quebec, Canada.

Abstract

The use of biobanks in biomedical research has grown considerably in recent years. As a result of the increasing analysis of tissue samples stored in biobanks, there has also been an increase in the probability of discovering-in addition to the research target-incidental findings (IF). We identified 23 laws, policies and guidelines from international, regional and national organizations that provide guidance or identify the need for the disclosure of IF to research participants. We analyzed these instruments to determine their contemplation of the funding considerations for the disclosure of IF, examining their guidance for who discloses and the extent of researcher responsibilities. We found that the available normative documents provide little guidance to researchers and biobanks for how they should address cost and funding concerns associated with IF disclosure. It is therefore essential that the research and policy communities think through the financial implications of imposing an ethical responsibility to disclose IF. Concerted efforts should be made by policymakers, ethicists, researchers, clinicians and research institutions to develop detailed funding recommendations, potentially universal in application, to aid in the disclosure of IF, and we provide recommendations on steps that can be taken to ensure full consideration of these issues.

KEYWORDS:

biobank; disclosure; ethics; incidental findings; research

PMID:
23662709
PMCID:
PMC4670700
DOI:
10.1111/cge.12190
[Indexed for MEDLINE]
Free PMC Article
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