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Acta Psychiatr Scand. 2013 Dec;128(6):434-47. doi: 10.1111/acps.12143. Epub 2013 May 10.

The neurobiological correlates of childhood adversity and implications for treatment.

Author information

1
Mood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, RI, USA; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.

Abstract

OBJECTIVE:

This article provides an overview of research on the neurobiological correlates of childhood adversity and a selective review of treatment implications.

METHOD:

Findings from a broad array of human and animal studies of early adversity were reviewed.

RESULTS:

Topics reviewed include neuroendocrine, neurotrophic, neuroimaging, and cognitive effects of adversity, as well as genetic and epigenetic influences. Effects of early-life stress on treatment outcome are considered, and development of treatments designed to address the neurobiological abnormalities is discussed.

CONCLUSION:

Early adversity is associated with abnormalities of several neurobiological systems that are implicated in the development of psychopathology and other medical conditions. Early-life stress negatively impacts treatment outcome, and individuals may require treatments that are specific to this condition.

KEYWORDS:

childhood abuse; early-life stress; neurobiology; treatment

PMID:
23662634
PMCID:
PMC4467688
DOI:
10.1111/acps.12143
[Indexed for MEDLINE]
Free PMC Article

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