Send to

Choose Destination
See comment in PubMed Commons below
Pulm Circ. 2013 Jan;3(1):116-20. doi: 10.4103/2045-8932.109926.

Transitioning from parenteral treprostinil to inhaled treprostinil in patients with pulmonary arterial hypertension.

Author information

Allegheny General Hospital, West Penn Allegheny Health System, Pittsburgh, Pennsylvania, USA.


Treprostinil is a potent prostacyclin vasodilator indicated for the treatment of pulmonary arterial hypertension (PAH, World Health Organization Group I). Previously, treprostinil was available only in subcutaneous (SC) or intravenous (IV) formulations. Availability of an inhaled formulation of treprostinil has provided clinicians with an alternative to continuous SC or IV treprostinil in appropriate patients. Stable PAH patients whose quality of life has been dramatically impacted by side effects of parenteral therapy or those who have had recurrent, life-threatening bloodstream infections but are otherwise responding well to treatment may be the candidates for continuing prostacyclin therapy with inhaled treprostinil. However, there is little clinical experience with transitioning patients from parenteral to inhaled treprostinil. We present the results of two cases that highlight important considerations in transitioning patients from parenteral to inhaled therapy, including the pharmacologic and clinical equivalence of formulations, dose titration of formulations and suggested criteria for patient selection.


case study; prostacyclin; prostanoid; pulmonary arterial hypertension; transition; treprostinil

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center