Format

Send to

Choose Destination
See comment in PubMed Commons below
Aust N Z J Psychiatry. 2013 Aug;47(8):710-27. doi: 10.1177/0004867413486842. Epub 2013 May 9.

Ketamine as a new treatment for depression: a review of its efficacy and adverse effects.

Author information

1
School of Psychiatry, University of New South Wales, Sydney, Australia.

Abstract

OBJECTIVE:

Narrative review of the literature on the efficacy and safety of subanaesthetic doses of ketamine for the treatment of depression.

METHOD:

Medline and PubMed databases were searched up to October 2012 using appropriate keywords.

RESULTS:

The studies consistently report substantial efficacy with high response and remission rates from 4 to 72 hours (averages 77% and 43%, respectively) from single doses, though not all patients respond to ketamine. Early relapse is common. While the usual procedure involves the administration of intravenous ketamine at a dose of 0.5 mg/kg over 40 minutes, some preliminary evidence suggests other dosing regimens and routes of administration may be useful or even better. Repeated doses and maintenance pharmacological treatments have been investigated in order to prolong the antidepressant effects, with only modest success.

CONCLUSIONS:

Current research on the antidepressant effects of ketamine has consistently shown rapid and substantial improvement in mood in the majority of patients. However, these effects have often been found to be short-lived. Future research should focus on identifying predictors of response (e.g. clinical, genetic, pharmacokinetic, environmental), examining different dosing regimens and routes of administration, and strategies to maintain the antidepressant response.

KEYWORDS:

Adverse effects; antidepressive agents; depressive disorder; ketamine; treatment outcome

PMID:
23661785
DOI:
10.1177/0004867413486842
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center