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Circulation. 2013 Jun 11;127(23):2316-26. doi: 10.1161/CIRCULATIONAHA.112.001290. Epub 2013 May 9.

Predictors of mortality and outcomes of therapy in low-flow severe aortic stenosis: a Placement of Aortic Transcatheter Valves (PARTNER) trial analysis.

Author information

1
Interventional Cardiology Program, Hospital of the University of Pennsylvania, 9038 Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104, USA. Howard.herrmann@uphs.upenn.edu

Abstract

BACKGROUND:

The prognosis and treatment of patients with low-flow (LF) severe aortic stenosis are controversial.

METHODS AND RESULTS:

The Placement of Aortic Transcatheter Valves (PARTNER) trial randomized patients with severe aortic stenosis to medical management versus transcatheter aortic valve replacement (TAVR; inoperable cohort) and surgical aortic valve replacement versus TAVR (high-risk cohort). Among 971 patients with evaluable echocardiograms (92%), LF (stroke volume index ≤35 mL/m(2)) was observed in 530 (55%); LF and low ejection fraction (<50%) in 225 (23%); and LF, low ejection fraction, and low mean gradient (<40 mm Hg) in 147 (15%). Two-year mortality was significantly higher in patients with LF compared with those with normal stroke volume index (47% versus 34%; hazard ratio, 1.5; 95% confidence interval, 1.25-1.89; P=0.006). In the inoperable cohort, patients with LF had higher mortality than those with normal flow, but both groups improved with TAVR (46% versus 76% with LF and 38% versus 53% with normal flow; P<0.001). In the high-risk cohort, there was no difference between TAVR and surgical aortic valve replacement. In patients with paradoxical LF and low gradient (preserved ejection fraction), TAVR reduced 1-year mortality from 66% to 35% (hazard ratio, 0.38; P=0.02). LF was an independent predictor of mortality in all patient cohorts (hazard ratio, ≈1.5), whereas ejection fraction and gradient were not.

CONCLUSIONS:

LF is common in severe aortic stenosis and independently predicts mortality. Survival is improved with TAVR compared with medical management and similar with TAVR and surgical aortic valve replacement. A measure of flow (stroke volume index) should be included in the evaluation and therapeutic decision making of patients with severe aortic stenosis.

CLINICAL TRIAL REGISTRATION:

URL: http://www.clinicaltrial.gov. Unique identifier: NCT0053089.4.

KEYWORDS:

aortic valve stenosis; blood flow velocity; heart valves

[Indexed for MEDLINE]

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