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Monolayer endoderm differentiation from human ESCs.


StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2012 Jun 10.


When embryonic stem cells are differentiated in the presence of activin A in serum-free conditions, an endoderm progenitor population defined by the coexpression of either Brachyury, Foxa2 and c-Kit, or c-Kit and Cxcr4 is generated. Specification of these progenitors with bone morphogenetic protein-4 in combination with basic fibroblast growth factor and activin A results in the development of hepatic populations highly enriched (45–70%) for cells that express the alpha-fetoprotein and albumin proteins.

Copyright: © 2012 X. Cheng , L. Ying, L. Lu , A.M. Galvão, J.A.Mills, H.C. Lin, D.N. Kotton, S.S. Shen, M.C. Nostro, J.K. Choi, M.J. Weiss, and D.L. French, P. Gadue.

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