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Transl Stroke Res. 2013 Jun;4(3):279-85. doi: 10.1007/s12975-012-0209-2. Epub 2012 Sep 5.

RIGOR guidelines: escalating STAIR and STEPS for effective translational research.

Author information

1
Department of Neurology, Cedars-Sinai Medical Center, Davis Research Building, D-2091, 110 N. George Burns Road, Los Angeles, CA 90048 USA.

Abstract

Stroke continues to be a serious and significant health problem in the USA and worldwide. This article will emphasize the need for good laboratory practices, transparent scientific reporting, and the use of translational research models representative of the disease state to develop effective treatments. This will allow for the testing and development of new innovative strategies so that efficacious therapies can be developed to treat ischemic and hemorrhagic stroke. This article recommends guidelines for effective translational research, most importantly, the need for study blinding, study group randomization, power analysis, accurate statistical analysis, and a conflict of interest statement. Additional guidelines to ensure reproducibility of results and confirmation of efficacy in multiple species are discussed.

KEYWORDS:

Brain; Clinical Trial; Hemorrhage; ICH; NIHSS; RIGOR; SAH; STAIR; STEPS; Stroke; Translational

PMID:
23658596
PMCID:
PMC3644408
DOI:
10.1007/s12975-012-0209-2
[Indexed for MEDLINE]
Free PMC Article
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