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Cancer Discov. 2013 May;3(5):494-6. doi: 10.1158/2159-8290.CD-13-0123.

Discovering what makes STAT signaling TYK in T-ALL.

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1
Department of Medicine and Pharmacology, Weill Cornell Medical College, New York, NY, USA.

Abstract

SUMMARY:

RNA interference screening establishes TYK2 dependence in T-cell acute lymphoblastic leukemia (T-ALL), leading to identification of TYK2-activating mutations and increased IL-10 receptor signaling in T-ALL cell lines. Cancer Discov; 3(5); 494-6. ©2013 AACR.

PMID:
23658297
DOI:
10.1158/2159-8290.CD-13-0123
[Indexed for MEDLINE]
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