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Curr Top Microbiol Immunol. 2014;373:69-86. doi: 10.1007/82_2013_321.

Central tolerance induction.

Author information

1
Diabetes Center, University of California-San Francisco, Box 0540, San Francisco, CA, 94143, USA.

Abstract

A critical function of the thymus is to help enforce tolerance to self. The importance of central tolerance in preventing autoimmunity has been enlightened by a deeper understanding of the interactions of developing T cells with a diverse population of thymic antigen presenting cell populations. Furthermore, there has been rapid progress in our understanding of how autoreactive T cell specificities are diverted into the T regulatory lineage. Here we review and highlight the recent progress in how tolerance is imposed on the developing thymocyte repertoire.

PMID:
23657830
DOI:
10.1007/82_2013_321
[Indexed for MEDLINE]

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