One-pot synthesis of 2,5-disubstituted pyrimidines from nitriles

J Org Chem. 2013 Jun 7;78(11):5800-3. doi: 10.1021/jo400720p. Epub 2013 May 22.

Abstract

A practical, one-step process for the synthesis of 2,5-disubstituted pyrimidines is presented. The protocol proved to be general for the synthesis of a variety of pyrimidine-containing compounds bearing an assortment of functional groups.

MeSH terms

  • Molecular Structure
  • Nitriles / chemistry*
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / chemistry

Substances

  • Nitriles
  • Pyrimidines