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Am J Reprod Immunol. 2013 Nov;70(5):347-58. doi: 10.1111/aji.12135. Epub 2013 May 9.

Plasma TNF-α levels are higher in early pregnancy in patients with secondary compared with primary recurrent miscarriage.

Author information

1
The Fertility Clinic, University Hospital Copenhagen, Rigshospitalet, Copenhagen, Denmark.

Abstract

PROBLEM:

Specific pro-inflammatory cytokine profiles in plasma may characterize women with recurrent miscarriage (RM) but the dynamics of the cytokine profiles with progressing pregnancy is largely unknown.

METHOD OF STUDY:

Plasma was repeatedly sampled in the first trimester from 47 RM patients. The concentrations of five cytokines including tumour necrosis factor alpha (TNF-α) were measured. TNF-α levels were correlated to carriage of five TNFA promoter polymorphisms.

RESULTS:

TNF-α levels increased (P = 0.014) with progressing pregnancy, with higher levels in secondary than primary RM (P = 0.042) but with no significant impact on outcome. Carriage of TNFA -863C and TNFA -1031T was associated with higher TNF-α levels, and the former was found more often in secondary than primary RM (P < 0.02).

CONCLUSION:

Plasma TNF-α levels increase during early pregnancy in RM women regardless of outcome, but are higher in secondary than primary RM, which may be partly genetically determined.

KEYWORDS:

Primary recurrent miscarriage; secondary recurrent miscarriage; tumour necrosis factor alpha dynamics; tumour necrosis factor alpha promoter polymorphism

PMID:
23656493
DOI:
10.1111/aji.12135
[Indexed for MEDLINE]

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