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Expert Rev Clin Pharmacol. 2013 May;6(3):235-41. doi: 10.1586/ecp.13.13.

Fixed-dose combination of phentermine-topiramate for the treatment of obesity.

Author information

1
Obesity & Metabolic Syndrome Unit, Division of Endocrinology & Metabolism, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil. brunohalpern@hotmail.com

Abstract

The aim of this article is to focus on the fixed-dose combination of phentermine and topiramate, a new antiobesity drug recently approved by the US FDA. The mechanisms of weight loss for each drug in monotherapy is described, followed by the rationale for its use as a combination therapy and a comprehensive review of recently published clinical trials that assessed its efficacy  and safety.

PMID:
23656337
DOI:
10.1586/ecp.13.13
[Indexed for MEDLINE]

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