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Appl Phys Lett. 2013 Apr 1;102(13):133702. Epub 2013 Apr 3.

Laser-enhanced cavitation during high intensity focused ultrasound: An in vivo study.

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KU Bioengineering Research Center, Department of Mechanical Engineering, University of Kansas, 1530 W. 15th Street, 5109 Learned Hall, Lawrence, Kansas 66045, USA.


Laser-enhanced cavitation during high intensity focused ultrasound (HIFU) was studied in vivo using a small animal model. Laser light was employed to illuminate the sample concurrently with HIFU radiation. The resulting cavitation was detected with a passive cavitation detector. The in vivo measurements were made under different combinations of HIFU treatment depths, laser wavelengths, and HIFU durations. The results demonstrated that concurrent light illumination during HIFU has the potential to enhance cavitation effect by reducing cavitation threshold in vivo.

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