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Nat Commun. 2013;4:1781. doi: 10.1038/ncomms2807.

Ribosomal protein S1 functions as a termination factor in RNA synthesis by Qβ phage replicase.

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Institute of Protein Research of the Russian Academy of Sciences, Pushchino, Moscow 142290, Russia.


S1 is the largest ribosomal protein, and is vitally important for the cell. S1 is also a subunit of Qβ replicase, the RNA-directed RNA polymerase of bacteriophage Qβ. In both protein and RNA syntheses, S1 is commonly believed to bind to a template RNA at the initiation step, and not to be involved in later events. Here, we show that in Qβ replicase-mediated RNA synthesis, S1 functions at the termination step by promoting release of the product strand in a single-stranded form. This function is fulfilled by the N-terminal fragment comprising the first two S1 domains. The results suggest that S1 might also have a role other than mRNA binding in the ribosome.

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