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Mucosal Immunol. 2014 Jan;7(1):101-13. doi: 10.1038/mi.2013.28. Epub 2013 May 8.

Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid.

Author information

1
1] INSERM Center of Research in Transplantation and Immunology, UMR1064, Nantes, France [2] CHU Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France [3] CHU Nantes, Laboratoire d'immunologie, Nantes, France [4] Faculté de Médecine, Université de Nantes, Nantes, France.
2
1] INSERM Center of Research in Transplantation and Immunology, UMR1064, Nantes, France [2] CHU Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France.
3
Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
4
Department of Gene and Cell medicine and the Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.
5
1] INSERM Center of Research in Transplantation and Immunology, UMR1064, Nantes, France [2] CHU Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France [3] Faculté de Médecine, Université de Nantes, Nantes, France.

Abstract

Interleukin-22 (IL-22) is mainly produced at barrier surfaces by T cells and innate lymphoid cells and is crucial to maintain epithelial integrity. However, dysregulated IL-22 action leads to deleterious inflammation and is involved in diseases such as psoriasis, intestinal inflammation, and cancer. IL-22 binding protein (IL-22BP) is a soluble inhibitory IL-22 receptor and may represent a crucial regulator of IL-22. We show both in rats and mice that, in the steady state, the main source of IL-22BP is constituted by a subset of conventional dendritic cells (DCs) in lymphoid and non-lymphoid tissues. In mouse intestine, IL-22BP was specifically expressed in lamina propria CD103(+)CD11b(+) DC. In humans, IL-22BP was expressed in immature monocyte-derived DC and strongly induced by retinoic acid but dramatically reduced upon maturation. Our data suggest that a subset of immature DCs may actively participate in the regulation of IL-22 activity in the gut by producing high levels of IL-22BP.

PMID:
23653115
PMCID:
PMC4291114
DOI:
10.1038/mi.2013.28
[Indexed for MEDLINE]
Free PMC Article

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