Format

Send to

Choose Destination
Sci Rep. 2013;3:1792. doi: 10.1038/srep01792.

Plasmon based biosensor for distinguishing different peptides mutation states.

Author information

1
Nanostructures, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy. gobind.das@iit.it

Abstract

Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.

PMID:
23652645
PMCID:
PMC3647166
DOI:
10.1038/srep01792
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center