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Pediatr Infect Dis J. 2013 Oct;32(10):1077-9. doi: 10.1097/INF.0b013e318299f75c.

Desired vancomycin trough serum concentration for treating invasive methicillin-resistant Staphylococcal infections.

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1
From the *Department of Pediatrics, Stanford University, Palo Alto, CA; †Department of Clinical Pharmacy, University of California San Francisco, CA; and ‡Department of Pediatrics, University of Utah, Salt Lake City, UT.

Abstract

Vancomycin area under the curve/minimal inhibitory concentration (AUC/MIC) >400 best predicts the outcome when treating invasive methicillin-resistant Staphylococcus aureus infection; however, trough serum concentrations are used clinically to assess the appropriateness of dosing. We used pharmacokinetic modeling and simulation to examine the relationship between vancomycin trough values and AUC/MIC in children receiving vancomycin 15 mg/kg every 6 hours and methicillin-resistant Staphylococcus aureus MIC of 1 μg/mL. A trough of 7-10 μg/mL predicted achievement of AUC/MIC >400 in >90% of children.

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PMID:
23652479
DOI:
10.1097/INF.0b013e318299f75c
[Indexed for MEDLINE]
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