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Nat Rev Microbiol. 2013 Jun;11(6):420-6. doi: 10.1038/nrmicro3030. Epub 2013 May 8.

Barriers to preclinical investigations of anti-dengue immunity and dengue pathogenesis.

Author information

1
Program in Emerging Infectious Diseases, Graduate Medical School, Duke-National University of Singapore, 8 College Road, 169857, Singapore.

Abstract

Dengue virus (DENV) is a human pathogen that causes severe and potentially fatal disease in millions of individuals each year. Immune-mediated pathology is thought to underlie many of the complications of DENV infection in humans, but the notable limitations of the available animal models have impeded our knowledge of the interactions between DENV and the immune system. In this Opinion article, we discuss some of the controversies in the field of dengue research relating to the interaction between DENV and the mammalian host. We highlight key barriers hindering our understanding of the molecular pathogenesis of DENV and offer suggestions for the most effective ways in which the role of the immune system in the protection from, and pathology of, DENV infection can be addressed experimentally.

PMID:
23652323
DOI:
10.1038/nrmicro3030
[Indexed for MEDLINE]

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