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Genes Dev. 2013 May 1;27(9):997-1002. doi: 10.1101/gad.215152.113.

The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo.

Author information

1
Developmental Biology Program, Sloan-Kettering Institute, New York, New York 10065, USA.

Abstract

Reciprocal inductive interactions between the embryonic and extraembryonic tissues establish the anterior-posterior (AP) axis of the early mouse embryo. The anterior visceral endoderm (AVE) signaling center emerges at the distal tip of the embryo at embryonic day 5.5 and translocates to the prospective anterior side of the embryo. The process of AVE induction and migration are poorly understood. Here we demonstrate that the T-box gene Eomesodermin (Eomes) plays an essential role in AVE recruitment, in part by directly activating the homeobox transcription factor Lhx1. Thus, Eomes function in the visceral endoderm (VE) initiates an instructive transcriptional program controlling AP identity.

KEYWORDS:

AVE; DVE Lhx1; Eomesodermin; Tbr2; axis formation; visceral endoderm

PMID:
23651855
PMCID:
PMC3656330
DOI:
10.1101/gad.215152.113
[Indexed for MEDLINE]
Free PMC Article
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