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Genes Dev. 2013 May 1;27(9):971-4. doi: 10.1101/gad.219147.113.

The family that eats together stays together: new p53 family transcriptional targets in autophagy.

Author information

1
Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

Abstract

Autophagy is a biological process that is crucial to maintain cellular homeostasis and is regulated by several metabolic pathways, including the p53 tumor suppressor pathway. In this issue of Genes & Development, Kenzelmann Broz and colleagues (pp. 1016-1031) show how the p53 family as a whole, including p63 and p73, collaborate in controlling autophagy to support tumor suppression.

KEYWORDS:

ChIP-seq; RNA-seq; autophagy; p53; tumor suppression

PMID:
23651851
PMCID:
PMC3656325
DOI:
10.1101/gad.219147.113
[Indexed for MEDLINE]
Free PMC Article

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