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Fertil Steril. 2013 Aug;100(2):478-82. doi: 10.1016/j.fertnstert.2013.04.017. Epub 2013 May 4.

Serum bisphenol-A concentration and sex hormone levels in men.

Author information

1
Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan, People's Republic of China.

Abstract

OBJECTIVE:

To evaluate the association between serum bisphenol-A (BPA) concentration and sex hormone levels in men.

DESIGN:

Cross-sectional study.

SETTING:

Not applicable.

PATIENT(S):

A total of 290 men with or without BPA exposure in the workplace.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Serum sex hormone levels.

RESULT(S):

After adjustment for potential confounders using linear regression, increasing serum BPA concentration was statistically significantly associated with [1] decreased androstenedione levels, [2] decreased free testosterone levels, [3] decreased free androgen index, and [4] increased sex hormone-binding globulin levels. Comparison of hormone levels between workers exposed and unexposed to BPA showed similar associations.

CONCLUSION(S):

Exposure to a high BPA level may impact sex hormone levels in men.

KEYWORDS:

BPA; Bisphenol-A; endocrine disruption; men; sex hormones

[Indexed for MEDLINE]

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