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Adv Appl Microbiol. 2013;83:69-86. doi: 10.1016/B978-0-12-407678-5.00002-7.

The Escherichia coli Nucleoid in Stationary Phase.

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Kavli Institute of Nanoscience, Delft University of Technology, Delft, The Netherlands.


Compaction of DNA is an essential phenomenon that affects all facets of cellular biology. Surprisingly, given the abundance and apparent simplicity of bacteria, our understanding of chromosome organization in these ancient organisms is inadequate. In this chapter we will focus on arguably the best understood aspect of DNA folding in the model bacterium Escherichia coli: the supercondensation of the chromosome that occurs during periods of starvation and stress.

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