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Philos Trans R Soc Lond B Biol Sci. 2013 May 6;368(1620):20120367. doi: 10.1098/rstb.2012.0367. Print 2013.

Chromatin organization and global regulation of Hox gene clusters.

Author information

1
National Research Centre 'Frontiers in Genetics', School of Life Sciences, Ecole Polytechnique Fédérale, Lausanne, Switzerland.

Abstract

During development, a properly coordinated expression of Hox genes, within their different genomic clusters is critical for patterning the body plans of many animals with a bilateral symmetry. The fascinating correspondence between the topological organization of Hox clusters and their transcriptional activation in space and time has served as a paradigm for understanding the relationships between genome structure and function. Here, we review some recent observations, which revealed highly dynamic changes in the structure of chromatin at Hox clusters, in parallel with their activation during embryonic development. We discuss the relevance of these findings for our understanding of large-scale gene regulation.

KEYWORDS:

chromatin architecture; collinearity; embryonic patterning; long-range regulation; nuclear organization

PMID:
23650639
PMCID:
PMC3682730
DOI:
10.1098/rstb.2012.0367
[Indexed for MEDLINE]
Free PMC Article

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