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Philos Trans R Soc Lond B Biol Sci. 2013 May 6;368(1620):20120362. doi: 10.1098/rstb.2012.0362. Print 2013.

Expression quantitative trait loci: present and future.

Author information

1
Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva 1211, Switzerland.

Abstract

The last few years have seen the development of large efforts for the analysis of genome function, especially in the context of genome variation. One of the most prominent directions has been the extensive set of studies on expression quantitative trait loci (eQTLs), namely, the discovery of genetic variants that explain variation in gene expression levels. Such studies have offered promise not just for the characterization of functional sequence variation but also for the understanding of basic processes of gene regulation and interpretation of genome-wide association studies. In this review, we discuss some of the key directions of eQTL research and its implications.

KEYWORDS:

expression quantitative trait loci; genetics; regulation

PMID:
23650636
PMCID:
PMC3682727
DOI:
10.1098/rstb.2012.0362
[Indexed for MEDLINE]
Free PMC Article

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