Format

Send to

Choose Destination
Arthritis Care Res (Hoboken). 2013 Aug;65(8):1381-4. doi: 10.1002/acr.21989.

Treatment of acute gouty arthritis in complex hospitalized patients with anakinra.

Author information

1
Kaiser Santa Clara Homestead Campus, Santa Clara, CA, USA.

Abstract

OBJECTIVE:

To report our experience with the efficacy and safety of anakinra for acute gouty arthritis in medically complex hospitalized patients.

METHODS:

We reviewed the hospital charts of 26 patients treated with anakinra for crystal-induced arthritis since 2007. Demographics, comorbid conditions, reason for anakinra use, response to treatment, and any adverse outcomes were recorded.

RESULTS:

Twenty-six patients received 40 courses of anakinra therapy. In 67% of patients, pain improved significantly within 24 hours, and complete resolution of signs and symptoms of gout occurred by day 5 in 72.5% of patients. Seven patients received multiple courses with no decrement in response with repeated treatments. Anakinra was well tolerated and no adverse outcomes were attributed to the medication. Only 1 patient appeared to be refractory to this form of interleukin-1 inhibition.

CONCLUSION:

Anakinra is an effective and safe alternative treatment for acute gouty arthritis in medically complex hospitalized patients who fail or cannot undergo more conventional therapy.

PMID:
23650178
DOI:
10.1002/acr.21989
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center