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Int J Cancer. 2014 Mar 1;134(5):1024-33. doi: 10.1002/ijc.28246. Epub 2013 Jun 4.

The receptor tyrosine kinase Axl in cancer: biological functions and therapeutic implications.

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1
International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa; Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa.

Abstract

The receptor tyrosine kinase Axl has been implicated in the malignancy of different types of cancer. Emerging evidence of Axl upregulation in numerous cancers, as well as reports demonstrating that its inhibition blocks tumor formation in animal models, highlight the importance of Axl as a new potential therapeutic target. Furthermore, recent data demonstrate that Axl plays a pivotal role in resistance to chemotherapeutic regimens. In this review we discuss the functions of Axl and its regulation and role in cancer development, resistance to therapy, and its importance as a potential drug target, focusing on acute myeloid leukemia, breast, prostate and non-small cell lung cancers.

KEYWORDS:

Axl; cancer; cancer therapy; drug resistance; receptor tyrosine kinases

PMID:
23649974
DOI:
10.1002/ijc.28246
[Indexed for MEDLINE]
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