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Eur J Pharmacol. 1990 Apr 10;179(1-2):217-9.

Biological activity of N-terminal fragments of calcitonin gene-related peptide.

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  • 1Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.

Abstract

The i.v. injection of human alpha-calcitonin gene-related peptide (CGRP) in urethane-anesthetized rats produced hypotension and tachycardia. The N-terminal fragments, CGRP-(1-12), CGRP-(1-15) and CGRP-(1-22) displayed biological activity, although with less potency than the natural peptide. These findings provide the first evidence for biological agonist activity of N-terminal CGRP fragments.

PMID:
2364983
[PubMed - indexed for MEDLINE]
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