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Clin Immunol. 2013 Jul;148(1):56-65. doi: 10.1016/j.clim.2013.03.010. Epub 2013 Mar 29.

The role of miR-155 in regulatory T cells and rheumatoid arthritis.

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Inserm U844, CHU Saint Eloi, INM, 80 rue Augustin Fliche, 34295 Montpellier cedex 5, France.


Recently, various micro(mi)RNAs have been found deregulated in the setting of rheumatoid arthritis (RA), but their role in the pathogenesis of this disease remains a matter of debate. In the meanwhile, increasing evidence indicates a defective function of regulatory T cells (Tregs) in RA. This review discusses relevant studies addressing the function of Tregs and Cytotoxic T-Lymphocyte Antigen 4 in RA, provides recent data on the role of miRNAs for Tregs homeostasis, and focuses on the role of miR-155 in Tregs. In a final perspective section we discuss the potential impact of therapeutic miR-155 modulation in RA.

[Indexed for MEDLINE]

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