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Clin Immunol. 2013 Jul;148(1):56-65. doi: 10.1016/j.clim.2013.03.010. Epub 2013 Mar 29.

The role of miR-155 in regulatory T cells and rheumatoid arthritis.

Author information

1
Inserm U844, CHU Saint Eloi, INM, 80 rue Augustin Fliche, 34295 Montpellier cedex 5, France. dspoerl@postmail.ch

Abstract

Recently, various micro(mi)RNAs have been found deregulated in the setting of rheumatoid arthritis (RA), but their role in the pathogenesis of this disease remains a matter of debate. In the meanwhile, increasing evidence indicates a defective function of regulatory T cells (Tregs) in RA. This review discusses relevant studies addressing the function of Tregs and Cytotoxic T-Lymphocyte Antigen 4 in RA, provides recent data on the role of miRNAs for Tregs homeostasis, and focuses on the role of miR-155 in Tregs. In a final perspective section we discuss the potential impact of therapeutic miR-155 modulation in RA.

PMID:
23649045
DOI:
10.1016/j.clim.2013.03.010
[Indexed for MEDLINE]

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