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Future Oncol. 2013 May;9(5):737-45. doi: 10.2217/fon.13.19.

ALDH7A1 expression is associated with recurrence in patients with surgically resected non-small-cell lung carcinoma.

Author information

1
Department of Radiation Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.

Abstract

AIM:

The purpose of this study was to describe the prognostic significance of ALDH7A1 in surgically treated non-small-cell lung carcinoma. (NSCLC).

MATERIALS & METHODS:

We immunohistochemically analyzed ALDH7A1 expression in surgically resected NSCLC from 89 patients using a tissue microarray.

RESULTS:

ALDH7A1 staining was positive in 43 patients and negative in 44 patients, with two tumor sections missing. For stage I NSCLC patients, ALDH7A1 positivity was associated with decreased recurrence-free and overall survival. Multivariate analysis demonstrated that ALDH7A1-expressing NSCLC tumors had a significantly higher incidence of lung cancer recurrence compared with patients with ALDH7A1-negative tumors, although there was no association with overall survival.

CONCLUSION:

For patients with NSCLC, low ALDH7A1 expression was associated with a decreased incidence of cancer recurrence. Specifically in stage I patients, negative staining for ALDH7A1 was associated with improved recurrence-free and overall survival, suggesting a predictive role in surgically treated patients.

PMID:
23647301
PMCID:
PMC5341386
DOI:
10.2217/fon.13.19
[Indexed for MEDLINE]
Free PMC Article

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