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Blood. 2013 Jun 13;121(24):4842-6. doi: 10.1182/blood-2013-03-456111. Epub 2013 May 3.

Long noncoding RNAs in biology and hematopoiesis.

Author information

1
Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Genome and transcriptome sequencing have revealed a rich assortment of noncoding RNAs in eukaryote cells, including long noncoding RNAs (lncRNAs), which regulate gene expression independent of protein coding potential. LncRNAs modulate protein coding gene expression in many cell types by regulating multiple processes, including epigenetic control of transcription, mRNA stability, and protein localization. Although little is known about lncRNAs in hematopoiesis, they are likely to exert widespread roles in this process.

PMID:
23645840
PMCID:
PMC3682336
DOI:
10.1182/blood-2013-03-456111
[Indexed for MEDLINE]
Free PMC Article

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