Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 2013 Jun;16(6):692-7. doi: 10.1038/nn.3392. Epub 2013 May 5.

GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior.

Author information

1
Epilepsy Research Laboratory, University of California, San Francisco, California, USA. robert.huntiii@ucsf.edu

Abstract

Impaired GABA-mediated neurotransmission has been implicated in many neurologic diseases, including epilepsy, intellectual disability and psychiatric disorders. We found that inhibitory neuron transplantation into the hippocampus of adult mice with confirmed epilepsy at the time of grafting markedly reduced the occurrence of electrographic seizures and restored behavioral deficits in spatial learning, hyperactivity and the aggressive response to handling. In the recipient brain, GABA progenitors migrated up to 1,500 μm from the injection site, expressed genes and proteins characteristic for interneurons, differentiated into functional inhibitory neurons and received excitatory synaptic input. In contrast with hippocampus, cell grafts into basolateral amygdala rescued the hyperactivity deficit, but did not alter seizure activity or other abnormal behaviors. Our results highlight a critical role for interneurons in epilepsy and suggest that interneuron cell transplantation is a powerful approach to halting seizures and rescuing accompanying deficits in severely epileptic mice.

PMID:
23644485
PMCID:
PMC3665733
DOI:
10.1038/nn.3392
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center