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Prostaglandins Other Lipid Mediat. 2013 Dec;107:95-102. doi: 10.1016/j.prostaglandins.2013.04.003. Epub 2013 May 2.

Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans.

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1
Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 - CNRS - University Montpellier I and II - ENSCM, Faculty of Pharmacy, Montpellier, France.

Abstract

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.

KEYWORDS:

Bioactive lipids; Biomarkers; Isoprostanes; Metabolites; Neuroprostanes; PUFAs

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