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Prostaglandins Other Lipid Mediat. 2013 Dec;107:95-102. doi: 10.1016/j.prostaglandins.2013.04.003. Epub 2013 May 2.

Isoprostanes and neuroprostanes: total synthesis, biological activity and biomarkers of oxidative stress in humans.

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Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 - CNRS - University Montpellier I and II - ENSCM, Faculty of Pharmacy, Montpellier, France.


Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.


Bioactive lipids; Biomarkers; Isoprostanes; Metabolites; Neuroprostanes; PUFAs

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