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Neurosci Lett. 2013 Jun 24;546:31-5. doi: 10.1016/j.neulet.2013.04.031. Epub 2013 May 2.

Antiepileptic effect of dimethyl sulfoxide in a rat model of temporal lobe epilepsy.

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Dipartimento di Bio-Medicina sperimentale e Neuroscienze cliniche, Sezione di Fisiologia umana G. Pagano, Università degli Studi di Palermo, Corso Tukory, 129, 90134 Palermo, Italy.


Dimethyl sulfoxide (DMSO) is an amphipathic molecule widely used to solubilize water-insoluble compounds. In many studies it was reported that DMSO is capable of affecting several biological processes, thus resulting in a potential cause for the misinterpretation of experimental data. Recent papers showed that DMSO modified the brain bioelectric activity in animal models of epilepsy. In an in vivo model of temporal lobe epilepsy in the rat, we examined the effects of different doses (10%, 50% and 100%) of DMSO on the maximal dentate activation (MDA). The results show that DMSO induced a dose-dependent significant reduction of the electrically induced paroxysmal activity.

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