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Am J Hum Genet. 2013 May 2;92(5):643-7. doi: 10.1016/j.ajhg.2013.03.017.

eXclusion: toward integrating the X chromosome in genome-wide association analyses.

Author information

1
National Human Genome Research Institute (NHGRI), Bethesda, MD, USA. anastasia.wise@nih.gov

Abstract

The X chromosome lags behind autosomal chromosomes in genome-wide association study (GWAS) findings. Indeed, the X chromosome is commonly excluded from GWAS analyses despite being assayed on all current GWAS microarray platforms. This raises the question: why are so few hits reported on the X chromosome? This commentary aims to examine this question through review of the current X chromosome results in the National Human Genome Research Institute Catalog of Published Genome-Wide Association Studies (NHGRI GWAS Catalog). It will also investigate commonly cited reasons for exclusion of the X chromosome from GWAS and review the tools currently available for X chromosome analysis. It will conclude with recommendations for incorporating X chromosome analyses in future studies.

PMID:
23643377
PMCID:
PMC3644627
DOI:
10.1016/j.ajhg.2013.03.017
[Indexed for MEDLINE]
Free PMC Article

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