Format

Send to

Choose Destination
Brain Res. 1990 May 21;516(2):310-2.

Fructose-1,6-bisphosphate reduces ATP loss from hypoxic astrocytes.

Author information

1
Department of Anesthesia, School of Medicine, University of California, San Francisco 94143.

Abstract

Hypoxia caused injury and metabolic dysfunction of astrocytes, as indicated by a time-dependent loss of lactate dehydrogenase (LDH) activity and ATP content. The combination of 3.5 mM fructose-1,6-bisphosphate (FBP) and 7.5 mM glucose (GLC) reduced the decrease of ATP and prevented the loss of LDH. These data indicate that the combination of GLC + FBP protects astrocytes from hypoxia. The results also suggest that the maintainance of ATP concentration is the mechanism by which FBP prevents hypoxic injury.

PMID:
2364296
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center