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J Cyst Fibros. 2013 Dec;12(6):790-3. doi: 10.1016/j.jcf.2013.04.003. Epub 2013 May 1.

Extensive diversification is a common feature of Pseudomonas aeruginosa populations during respiratory infections in cystic fibrosis.

Author information

1
Regional Adult Cystic Fibrosis Unit, Liverpool Heart and Chest Hospital, Liverpool L14 3PE, United Kingdom.

Abstract

BACKGROUND:

Populations of the Liverpool Epidemic Strain (LES) of Pseudomonas aeruginosa undergo extensive diversification in the cystic fibrosis (CF) lung during long-term chronic infections.

METHODS:

We analyzed sets of 40 isolates from the sputa of five CF patients, each chronically infected with a different non-LES strain of P. aeruginosa. For each sample (two per patient), diversity was assessed by characterizing nine phenotypic traits.

RESULTS:

All P. aeruginosa populations were highly diverse, with the majority of phenotypic variation being due to within-sample diversity.

CONCLUSIONS:

Maintenance of diverse populations in the CF lung is a common feature of P. aeruginosa infections.

KEYWORDS:

Cystic fibrosis; Population biology; Pseudomonas aeruginosa

PMID:
23642644
PMCID:
PMC3851688
DOI:
10.1016/j.jcf.2013.04.003
[Indexed for MEDLINE]
Free PMC Article

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