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ChemMedChem. 2013 Jun;8(6):928-33. doi: 10.1002/cmdc.201300120. Epub 2013 May 2.

Synthesis, antitumor evaluation and docking study of novel 4-anilinoquinazoline derivatives as potential epidermal growth factor receptor (EGFR) inhibitors.

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1
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China. rgw@zjut.edu.cn

Abstract

Strike a pose! A series of 4-anilinoquinazolines were designed, synthesized and evaluated in vitro against lung and breast cancer cell lines. Several compounds were found to be endowed with cytotoxicity in the low micromolar range. Molecular docking suggests that these compounds bind to EGFR in a similar manner to known EGFR inhibitors.

PMID:
23640754
DOI:
10.1002/cmdc.201300120
[Indexed for MEDLINE]
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