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Saudi J Kidney Dis Transpl. 2013 May;24(3):557-60.

Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid transformation.

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Department of Histopathology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.


Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a recently described entity in the World Health Organization (WHO) 2004 classification and has a relatively indolent behavior. Sarcomatoid differentiation has been well documented in most histologic variants of renal cell carcinoma and its presence is known to have a worse prognosis. Its occurrence in an otherwise benign MTSCC is extremely rare. Here, we report a unique case of MTSCC in a 64-year-old patient with multiple areas of high-grade spindle cells and large areas of necrosis in it. The patient had a rapidly fatal clinical outcome.

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