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Pediatr Clin North Am. 2013 Jun;60(3):669-88. doi: 10.1016/j.pcl.2013.02.006. Epub 2013 Mar 13.

Acute kidney injury in children: an update on diagnosis and treatment.

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Critical Care Division, Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta at Egleston, Atlanta, GA 30322, USA.


The concept and definition of acute kidney injury (AKI) in adults and children has undergone significant change in recent years. Biomarker assessment is aiding in description, defining and understanding timing of AKI. AKI demonstrates unique characteristics in association with sepsis and septic shock, organ dysfunction, and fluid overload. Treatment remains problematic, but growing experience with pediatric continuous renal replacement therapies has improved the delivery of care in children. Increasingly, continuous renal replacement therapy is provided in combination with other extracorporeal technologies, and approaches are advancing to improve combined therapy use.

[Indexed for MEDLINE]

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