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Gastroenterol Clin North Am. 2013 Jun;42(2):285-98. doi: 10.1016/j.gtc.2013.01.006. Epub 2013 Mar 6.

Helicobacter pylori in gastric carcinogenesis: mechanisms.

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1
Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.

Abstract

Helicobacter pylori infection induces chronic inflammation and is the strongest known risk factor for gastric cancer. The genomes of H pylori are highly diverse and therefore bacterial virulence factors play an important role in determining the outcome of H pylori infection, in combination with host responses that are augmented by environmental and dietary risk factors. It is important to gain further understanding of the pathogenesis of H pylori infection to develop more effective treatments for this common but deadly malignancy. This review focuses on the specific mechanisms used by H pylori to drive gastric carcinogenesis.

PMID:
23639641
PMCID:
PMC3648881
DOI:
10.1016/j.gtc.2013.01.006
[Indexed for MEDLINE]
Free PMC Article

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