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Transplant Rev (Orlando). 2013 Jul;27(3):65-75. doi: 10.1016/j.trre.2013.03.001. Epub 2013 Apr 30.

Immunosenescence and organ transplantation.

Author information

1
Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Abstract

Increasing numbers of elderly transplant recipients and a growing demand for organs from older donors impose pressing challenges on transplantation medicine. Continuous and complex modifications of the immune system in parallel to aging have a major impact on transplant outcome and organ quality. Both, altered alloimmune responses and increased immunogenicity of organs present risk factors for inferior patient and graft survival. Moreover, a growing body of knowledge on age-dependent modifications of allorecognition and alloimmune responses may require age-adapted immunosuppression and organ allocation. Here, we summarize relevant aspects of immunosenescence and their possible clinical impact on organ transplantation.

PMID:
23639337
PMCID:
PMC3718545
DOI:
10.1016/j.trre.2013.03.001
[Indexed for MEDLINE]
Free PMC Article

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