Format

Send to

Choose Destination
Curr Opin Cell Biol. 2013 Aug;25(4):414-9. doi: 10.1016/j.ceb.2013.04.002. Epub 2013 Apr 29.

Rab GTPase regulation of membrane identity.

Author information

1
Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive B400, Stanford, CA 94305-5307, USA. pfeffer@stanford.edu

Abstract

A fundamental question in cell biology is how cells determine membrane compartment identity and the directionality with which cargoes pass through the secretory and endocytic pathways. The discovery of so-called 'Rab cascades' provides a satisfying molecular mechanism that helps to resolve this paradox. One Rab GTPase has the ability to template the localization of the subsequent acting Rab GTPase along a given transport pathway. Thus, in addition to determining compartment identity and functionality, Rab GTPases are likely able to order the events of membrane trafficking. This review will highlight recent advances in our understanding of Rabs and Rab cascades.

PMID:
23639309
PMCID:
PMC3729790
DOI:
10.1016/j.ceb.2013.04.002
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center