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Ann Clin Psychiatry. 2013 Aug;25(3):186-92. Epub 2013 May 1.

Antidepressant-induced excessive sweating: clinical features and treatment with terazosin.

Author information

1
Department of Psychiatry and Human Behavior, Jefferson Medical College, 833 S. Chestnut Street, Philadelphia, PA 19107, USA. rajnish.mago@jefferson.edu

Abstract

BACKGROUND:

Antidepressant-induced excessive sweating (ADIES) occurs in 5% to 14% of patients taking antidepressants, usually persists throughout treatment, and causes subjective distress and functional impairment. We conducted the first clinical trial of any treatment for ADIES.

METHODS:

Clinical features of ADIES were assessed using a semi-structured form. Twenty-three patients with moderate or greater ADIES were assessed for a 2-week baseline period , followed by 6 weeks of open-label treatment with flexible dose terazosin, 1 to 6 mg/d. Improvement in ADIES was measured by the Clinical Global Impressions (CGI) scale and other measures.

RESULTS:

ADIES commonly was prominent in the scalp (62%), face (95%), neck (48%), and chest (57%); usually occurred either episodically or with episodic bursts (82%); and was persistent (median 63 months). Twenty-two of the 23 patients responded to terazosin (CGI-I scores 1 or 2), with CGI-Severity improving from median of 5 to median of 2 (P < .0001). Patient-rated daytime and nighttime severity of ADIES and proportion of time in ADIES also improved significantly. The most common adverse effects of terazosin therapy were dizziness/lightheadedness (n = 9) and dry mouth (n = 4). No patient dropped out because of adverse effects. Sitting and standing systolic blood pressure decreased by median values of 3 (P = .044) and 5 (P = .063) mm Hg, respectively.

CONCLUSIONS:

Terazosin may be an effective treatment for ADIES. Although dizziness/lightheadedness may occur in some patients, the treatment generally was well tolerated.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00237510 NCT00449683.

PMID:
23638448
[Indexed for MEDLINE]

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