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Nat Rev Mol Cell Biol. 2013 Jun;14(6):393-8. doi: 10.1038/nrm3581. Epub 2013 May 2.

Signalling change: signal transduction through the decades.

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1
Friedrich Miescher Institute for Biomedical Research, and University of Basel, Basel, Switzerland. nancy.hynes@fmi.ch

Abstract

The past few years have marked significant anniversaries in signal transduction, including the identification of classic growth factors and morphogens, the notion of protein modification through phosphorylation and the characterization of protein interaction domains. Here, six researchers reflect on the context in which these discoveries were made, and how our concept of cell signalling has evolved during the past three decades.

PMID:
23636498
DOI:
10.1038/nrm3581
[Indexed for MEDLINE]
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