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Nucl Med Commun. 2013 Jul;34(7):682-8. doi: 10.1097/MNM.0b013e328361cd0e.

Diagnostic performance of 18F-FDG PET/CT in patients with fever of unknown origin: a meta-analysis.

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1
Medical Healthcare Center, Beijing Friendship Hospital of Capital Medical University, Beijing, People's Republic of China.

Abstract

PURPOSE:

The aim of this study was to systematically review and perform a meta-analysis of published data on the diagnostic value of F-fluorodeoxyglucose (F-FDG) PET/CT in the diagnosis of patients with fever of unknown origin (FUO).

MATERIALS AND METHODS:

A comprehensive computer literature search of studies published through 31 March 2012 on the use of F-FDG PET/CT in patients with FUO was performed in PubMed/MEDLINE, Embase, and Scopus databases. The pooled sensitivity of F-FDG PET/CT in patients with FUO on a per-patient-based analysis was calculated. The area under the receiver-operating characteristic curve was calculated to measure the accuracy of F-FDG PET/CT in the diagnosis of patients with FUO.

RESULTS:

Fifteen studies comprising 595 patients with FUO were included in this meta-analysis. The pooled sensitivity of F-FDG PET/CT in detecting the cause of FUO was 85% (95% confidence interval 81-88%) on a per-patient-based analysis. The area under the receiver-operating characteristic curve was 0.88.

CONCLUSION:

F-FDG PET/CT demonstrated high sensitivity for the diagnosis of patients with FUO. F-FDG PET/CT is an accurate technique in this setting, but the possibility of false-positive results should be kept in mind. This meta-analysis demonstrated the value of F-FDG PET/CT in the diagnosis of patients with FUO.

PMID:
23636293
DOI:
10.1097/MNM.0b013e328361cd0e
[Indexed for MEDLINE]
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