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Physiology (Bethesda). 2013 May;28(3):172-89. doi: 10.1152/physiol.00055.2012.

Transduction of voltage and Ca2+ signals by Slo1 BK channels.

Author information

1
Department of Physiology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Abstract

Large-conductance Ca2+ -and voltage-gated K+ channels are activated by an increase in intracellular Ca2+ concentration and/or depolarization. The channel activation mechanism is well described by an allosteric model encompassing the gate, voltage sensors, and Ca2+ sensors, and the model is an excellent framework to understand the influences of auxiliary β and γ subunits and regulatory factors such as Mg2+. Recent advances permit elucidation of structural correlates of the biophysical mechanism.

PMID:
23636263
PMCID:
PMC3742125
DOI:
10.1152/physiol.00055.2012
[Indexed for MEDLINE]
Free PMC Article

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